Bologna – Istituto Rizzoli
Misano Adriatico – Mendel
San Marino – Nova Clinic
Roma – Salvator Mundi
San Lucido – Studi Medici ARS

Stem cells

In the orthopaedic field, the use of (mesenchymal) stem cells is now an established practice for the treatment of medium to severe arthrosis. [3]

Mesenchymal cells are primitive, non-specialised cells that can transform into different cell lines; they can be harvested from bone marrow or subcutaneous adipose tissue (Fig. 1). [1]

Cellule staminali
Fig.1 Cellule staminali (mesenchimali) detivate dal tessuto adiposo sottocutaneo.

They can be harvested either from the abdomen from which a small amount of adipose tissue is extracted, or from the iliac crest from which bone marrow tissue is harvested minimally invasively. [2] The mesenchymal cells once harvested are processed, concentrated and then injected into the joint. The procedure is performed under local anaesthesia (without the patient being put to sleep) and can be completed in approximately one hour. Recovery time after undergoing the procedure is very short. The effect of the treatment is pain relief and improved joint motility. Currently, 1/2-year follow-up results of this type of procedure are available and are very encouraging, both on the knee [4] as well as on the hip [5] and shoulder. [6]

MICRO-FRAGMENTED ADIPOSE TISSUE AUTO-TRANSPLANTATION With CRIOCONSERVATION

Bibliografy
  1. Mesenchymal stem cells in joint disease and repair. Barry F, Murphy M. Nat Rev Rheumatol. 2013;9:584–594.
  2. Bone Marrow-Derived and Adipose-Derived Mesenchymal Stem Cell Therapy in Primary Knee Osteoarthritis: A Narrative Review. Jayaram P, Ikpeama U, Rothenberg JB, Malanga GA. PM R. 2019;11:177–191.
  3. The efficacy of different sources of mesenchymal stem cells for the treatment of knee osteoarthritis. Shariatzadeh M, Song J, Wilson SL. Cell Tissue Res. 2019;378:399–410.
  4. Safety and Efficacy of Percutaneous Injection of Lipogems Micro-Fractured Adipose Tissue for Osteoarthritic Knees. Panchal J, Malanga G, Sheinkop M. Am J Orthop (Belle Mead NJ). 2018 Nov;47(11).
  5. Mesenchymal Stem Cells injection in hip osteoarthritis: preliminary results. Dall’Oca C, Breda S, Elena N, Valentini R, Samaila EM, Magnan B. Acta Biomed. 2019 Jan 10;90(1-S):75-80.
  6. Clinical use of autologous micro-fragmented fat progressively restores pain and function in shoulder osteoarthritis. Vinet-Jones H, F Darr K. Regen Med. 2020 Oct;15(10):2153-2161.

Book online